Indigenous groups:

There are semi nomad indigenous groups of the Sikuani-Guahíbo and Cuiba ethnicities within the protected area and, in the area of influence of the Park. There are Curripaco and Puivane indigenous groups settled in the Carestía and Pedro Camejo Islands; permanent settlements of Sikuani of El Guamito, San Luis and the Cachicamo belonging to the Piraoa group.

Settlers and floating population:

There is also a population of mestizo settlers with extractive habits living in the vicinity of the Park, who arrived to the area fleeing from violence and attracted by illicit economic activities.