• One of the most important reasons warranting for the preservation of NNP Sierra de La Macarena is its high endemic population of fauna and flora. Available information on the subject is currently being reviewed, as there is preliminary data suggesting the presence of over twenty species of flora and as many fauna species combining fish, fowls and mammals.

Endemic flora: Calymperes uleanum, Connarus perturbatus, Hirtella adenophora, Hirtella maguirei, Anime Asplundia rhodea, Gustavia macarenensis, Inga macarenensis, Sterculia guapayensis, Zapito or Zapotillo Sterculia macarenensis, red alga, Macarenia clavigera, deer horn Vellozia macarenensis, Piper echinovarium and Licania lasseri (Cormacarena, 2001.)

It also possible to find imposing trees of great commercial interest, such as the Cedrela tonduzii, Cedrela odorata, Aniba sp., Calophylum lucidum, Centrolobium paraense, Ocotea, Sterculia macaranensis, Bombacopsis quinata, Ceiba bonga, Tratinickia aspera, Nectandra spp., Dacryodes colombiana, Jacaranda copala, Terminalia amazonica.

From the 2012 surface analysis for the NNP Sierra de La Macarena, with 605793 hectares as base amount, it was determined that 11% of the total area of the park is intervened in as much as 66960 hectares under categories such as fragmented forest with grass and crops, mosaic of crops and natural spaces, mosaic of crops, natural spaces and grass, mosaic of grass with natural spaces, mosaic of grass and crops, thicket, clean grass and burned zones with a total of 44818 hectares. Additionally, surfaces undergoing natural recovery known as fragmented forest with secondary vegetation, and secondary vegetation or in transition with a total of 22142 hectares, along with those presumed to be undergoing natural regeneration.