The Park is habitat to 44 of the 340 endemic species registered for Colombia and to 49 of the 3,057 endangered species of Colombia. Some of the most significant ones are the condor (Vultur gryphus), danta or tapir (Tapirus kabomani), jaguar (Panthera onca), paujil (Crax alberti) and páramo deer (Mazama rufina). All of these species are included in different categories of threat according to the criteria of the International Union for Conservation of Nature (IUCN).